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Pifithrin-α (PFTα) br Fig PPM D and SPOP attenuated the inhi
2020-08-03
Fig. 5. PPM1D and SPOP attenuated the inhibition of cell proliferation induced by APPBP2 knockdown in NSCLC cells. (a) Ectopic expression of PPM1D or SPOP promoted colon formation on APPBP2 silenced A549 cells. Control was set as a blank group without protein overexpression. (b) The statistical re
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br Fig Proliferation inhibition of Mel Rm cell
2020-08-02
Fig. 17. Proliferation inhibition of Mel-Rm cell lines by L-Dopa, [email protected], and [email protected]@L-Dopa after 24 h. The Ifenprodil hemitartrate were counted by the MTT. There were three Groups: Group I: incubated with L-Dopa, Group II: incubated with [email protected]@L-Dopa, and Group III:
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br Cellular uptake of nano lipobubbles
2020-08-02
3.5. Cellular uptake of nano-lipobubbles Formulated CHO- and DSPE-NLBs demonstrated a time-dependent cellular uptake, which was more pronounced in the CHO-NLBs. The distinct increase in fluorescence intensity evident in the fluorescence micrographs in the upper panel of Fig. 3 highlights the in
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br Disclosure of interest br The authors declare
2020-07-28
Disclosure of interest The authors declare that they Calcipotriol have no competing interest. References [1] Harif M, Barsaoui S, Benchekroun S, et al. Traitement des cancers de l’enfant en Afrique : re´sultats pre´liminaires du groupe francoafricain d’oncologie pe´dia-trie. Arch Pe´diat
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br Introduction br Iron is a metal that is essential
2020-07-27
1. Introduction Iron is a metal that is essential to life, yet it is toxic in excess. In healthy individuals, the metabolic requirement for iron is achieved by a complex homeostatic network strictly regulated at both systemic and cellular levels, in which the organism absorb from diet only the
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br HP infection HPI and gastric mucosal
2020-07-25
3.3. HP infection (HPI) and gastric mucosal dysbiosis To investigate whether HP colonisation influences the overall struc-ture and composition of the gastric microbiota in specific microhabitats, we examined changes in the gastric microbiota in patients with histo-pathological HP+ and H. pyl
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br Conclusion br This study confirmed the role of
2020-03-24
7. Conclusion This study confirmed the role of FABP-4 as an adipokine in pathogenesis of type 2 DM, breast cancer & diabetic subjects with breast cancer via enhancing angiogenesis (increased serum VEGF), inflammatory biomarkers (increased serum TNF-a) and oxidative stress (increased serum 8-OHd
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br Downregulation of ADD and ADD enhances
2020-03-24
3.2. Downregulation of ADD1 and ADD3 enhances individual migration of NSCLC cells To investigate the roles of adducins in the regulation of lung cancer cell motility, we deleted either ADD1 or ADD3 in epithelial-type H1573 and 16HBE14o Ko 143 by using CRISPR/Cas9-mediated gene editing. Cells w
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br resulted in decreased anti apoptotic MCL expression In
2020-03-24
resulted in decreased anti-apoptotic MCL1 expression. In contrast, the expression of pro-apoptotic BAX and BIM were increased upon metformin treatment. Part of the effects of metformin may be due to miR-26a expression as metformin increased its expression. miR-26a mimics also decreased MCL1 express
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br Our future research will focus on
2020-03-24
Our future research will focus on the following important issues. First, it would be valuable to verify the proposed model on a larger real dataset from more data sources. Secondly, it would be of interest to apply the proposed method to prognosis prediction of other cancers with a high incidence
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Participants linked resistance to the HPV
2019-11-12
Participants linked resistance to the HPV vaccine for boys and young men with gender norms. One 30 year-old African American participant stressed, “people need to be aware, especially … our young men because they're a little more brave than females are because they sort of kind of feel invincible.”
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br In this study in order to realize the controlled
2019-11-05
In this study, in order to realize the controlled and targeted delivery of DOX, a light-responsive amphiphile, HA-NB-SC, was synthesized, and was used as a vehicle for targeted cancer therapy (Scheme 1). HA-NB-SC was characterized by nuclear magnetic resonance (NMR), fourier transform infrared (FT
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br YKK was a consultant
2019-11-05
YKK was a consultant for Blueprint, Bristol-Meyers Squibb, Daehwa, LSK Biopharma, Merck Serono, Novartis, Ono and Roche. HCC has received research grants from Eli Lilly, GlaxoSmithKline, Merck Serono, Merck Sharp & Dohme, Ono and Taiho, served on speakers bureaus for Eli Lilly, Foundation Medic
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br These results agreed with those obtained with NP
2019-10-22
These results agreed with those obtained with NP intracellular up-take and suggest that PLGA NPs enhance cellular internalisation of PTX, which is a notable advantage over the free drug. Interestingly, the in-tracellular PTX concentration remained constant in lung tumor cell lines following
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br primer CTGGATCCAAGACCAGGGTG and reverse GTGAGGAC TCCAGCCA
2019-10-21
primer 5′-CTGGATCCAAGACCAGGGTG-3′ and reverse 5′-GTGAGGAC TCCAGCCACAAA-3′, product length 145 bps; Caspase-3 forward primer 5′-AGCTTGGAACGGTACGCTAA-3′ and reverse 5′-CCACTGACTTGCTC CCATGT-3′, product length 145 bps; Caspase-9 forward primer 5′-CAC CTTCCCAGGTTGCCAAT-3′ and reverse 5′- CAAGCCATGAGAG