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br This paper presents a potent
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This paper presents a potent approach for the automated classifi-cation of cervical cancer from Pap smears using an enhanced fuzzy c- Informatics in Medicine Unlocked 14 (2019) 23–33 Fig. 1. The approach to achieve cervical cancer classification from Pap smear images. means algorithm. A
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br Measurement of IFN and IL secretion
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2.6. Measurement of IFN-γ and IL-4 secretion from splenocytes The cell potential of IFN-γ and IL-4 secretion from mice splenocytes was examined with an Enzyme-Linked ImmunoSpot (ELISpot) kit (Mabtech AB, Sweden) as per the manufacturer’s protocol following immunization with liposomes. In brief,
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br There is increasing evidence that TAM accumulation is ass
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There is increasing evidence that TAM accumulation is associated with poor clinical prognosis and resistance to cancer therapy, which is in part due to the immunosuppressive and tumor-promoting activities of TAMs (Cassetta and Pollard, 2018). Recently, several studies on TAM-targeting cancer thera
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br c Institute of Translational Medicine College of
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c Institute of Translational Medicine, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211800, China d Department of Pathology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029,
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CT-99021 br We then purified CX derived from C formosum ssp
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We then purified CX derived from C. formosum ssp. pruniflorum as described in the Materials and Methods section and treated A549RT-eto CT-99021 with CX. The molecular structure of CX is shown in Fig. 1C. (A) Cell lysates from A549 and A549RT-eto cells were prepared and separated on 8% SDS-PAGE
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br Declaration of Competing Interest br The authors declare
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Declaration of Competing Interest “The authors declare no potential conflicts of interest”. Acknowledgements References Bubnovskaya, L., Kovelskaya, A., Gumenyuk, L., Ganusevich, I., Mamontova, L., Mikhailenko, V., Osinsky, D., Merentsev, S., Osinsky, S., 2014. Disseminated tumor 2642-
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br Wojnar A Kobierzycki C Krolicka A Pula
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Wojnar, A., Kobierzycki, C., Krolicka, A., Pula, B., Podhorska-Okolow, M., and Dziegiel, P. (2010). Correlation of Ki-67 and MCM-2 proliferative marker α-Linolenic Acid with grade of histological malignancy (G) in ductal breast cancers. Folia Histochem. Cytobiol. 48, 442–446. STAR+METHODS K
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br Fig Bou inhibits the growth
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Fig. 5. Bou inhibits the growth of rectal cancer in a xenograft mouse model. HCT-116 BMS-936558 (1 × 107 cells per mouse) were injected subcutaneously into the dorsal flank of nude mice. Once the tumors reached approximately 75 mm3, mice received a daily i.p. injection of either vehicle control (
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br introduction of normal mitochondria into cancer cells
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introduction of normal mitochondria into cancer Pentostatin could reverse their malignancy, growth, invasion and drug resistance (Kaipparettu et al., 2013). Therefore, increasing the mitochondrial oxidation of substrates may suppress cancer growth by denying the substrates re-quired for the Warbu
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br CIN is of particular interest because it is
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[58]. CIN is of particular interest because it is associated with aggressive tumors, the acquisition of drug resistance, and poor patient prognosis [59–62]. Multiple investigations described genome instability in ovarian cancer [63–65], which is characterized by gene copy number variations, rearra
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br Luciferase reporter assay br The UTR
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2.7. Luciferase reporter assay The 3’-UTR of human TRIM25 mRNA was constructed with synthetic oligo-nucleotides and cloned in between the Sac I and Xho I sites of the pmirGLO Dual-luciferase miRNA target expression vector (Promega). We constructed pmirGLO-TRIM25 wild-type (WT) and pmirGLO-TRIM2
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br Subsequently the cytotoxicity of BP DACHPt in
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Subsequently, the cytotoxicity of BP/DACHPt in air-exposed water after 72 h was quantified with the MTT assay. As displayed in Fig. 3B and S13, BP/DACHPt is cytotoxic against HeLa 322455-70-9 in a concentration-dependent manner without NIR laser irradiation. After irradiation, the survival rates
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br This paper has been recommended
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* This paper has been recommended for acceptance by Dr. Payam Dadvand. * Corresponding author. E-mail address: [email protected] (Z. Cai). 1 These authors contributed equally to this work. emerging pollutant (Liao et al., 2012a,b,c). BPS can be found in many commercial products labeled
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NCT-501 br Fig Migration capacity of the implanted MIA
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Fig. 6. Migration capacity of the implanted MIA NCT-501 and PSCs in zebrafish. MIA cells and PSCs were co-cultured for 48 h, and injected in zebrafish embryos at 4 hpf. Cell migration in the representative embryos was tracked from 24 to 72 hpf. MIA-PSC cells derived from TCPS and CS-HA substrates
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br Fig Overexpression of Cx
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Fig. 6. Overexpression of Cx43 enhances sensitivity of MDA-MB-231 MTT to Av treatment. (A) Western blot analysis of total protein obtained from cell lysates of Av-treated MDA-Cx43D cells for NF-κB p65 and GAPDH. (B) Densitometric quantification of NF-κB p65. (C&D) Immunofluorescence staining of R